Can a plant-based diet help mitigate Covid-19?

Hana Kahleova & Neal D. Barnard

As Covid-19 resurges, propelled by the emergence of the omicron variant, and by the reduced effectiveness of the Covid vaccines over time [1], many people are asking what can be done to prevent “breakthrough” infections in vaccinated people and what can turn the tide on the pandemic overall. Recent studies show what may be a surprising answer.

The effectiveness of vaccination, as measured by antibody titres, may be significantly reduced by the presence of chronic conditions, particularly central obesity, hypertension, dyslipidemia, and smoking [2]. Covid-19 deaths are considerably more common in the context of advanced age or chronic diseases, such as excess body weight, coronary heart disease, hypertension, type 2 diabetes, and chronic lung disease. In turn, these conditions are strongly linked to diet and lifestyle choices that can be changed. Indeed, those people who have made lifestyle changes have demonstrable protection against the virus. Analyzing data from 592,571 participants, Merino et al. showed that a dietary pattern characterized by healthy plant-based foods was associated with a 9% lower risk of Covid-19 infection and a 41% lower risk of severe Covid-19 [3]. The dietary data from 568 Covid-19 cases and 2316 controls from healthcare workers from six countries (France, Germany, Italy, Spain, UK, USA) with substantial exposure to Covid-19 patients have demonstrated that those following a plant-based diet had a 73% lower risk of moderate-to-severe Covid-19 [4].

Needless to say, plant-based diets were already beneficial for human health before the emergence of SARS-CoV-2. The Global Burden of Disease Study showed that low fruit, vegetable, and whole grain consumption, and, in contrast, high red and processed meat consumption are currently among the main global risks [5]. Proper nutrition may help prevent almost half of cardio-metabolic deaths in the US [5]. Specifically, a plant-based diet seems to decrease all-cause mortality and risk of obesity, type 2 diabetes, and coronary heart disease, partly by effectively improving nutrient intake [6], and thereby addressing the underlying health conditions that put our population at such a great risk of severe Covid mortality and morbidity.

In the context of Covid-19, we can draw a lesson from the “Blue Zones,” areas of particularly high longevity [7]. People in Okinawa, for example, consume a predominantly plant-based diet rich in phytochemicals and antioxidants, with over half of their daily caloric intake coming from sweet potatoes. They also consume abundant green leafy vegetables and soy products, with minimal fat (about 6% of the total energy intake) [8].

In addition to their high life expectancy and low mortality from cardiovascular disease and certain types of cancers, Okinawans have enjoyed a remarkable resistance to Covid-19 mortality. As of June 16, 2021, the Covid-19 mortality in Okinawa, Japan, was 0.08% (163 deaths out of 19,782 cases), which is one-sixteenth that of Tokyo (mortality rate 1.3%; 2183 deaths out of 167,416 cases) [9]. Okinawa is roughly the size of Tokyo, and vaccination rates in July were low in both. Lower population density in Okinawa could partly explain the lower Covid-19 toll. But it is likely that the remarkably low prevalence of chronic diseases in Okinawa has been a major factor.

In order to tackle the challenges of the Covid-19 delta variant surge, we must address the major lifestyle risk factors, such as smoking, lack of physical activity, and, most of all, poor diet. Adopting a healthful plant-based diet and lifestyle is a powerful tool which may delay the aging process, decrease age-associated co-morbidities, and decrease the risk of severe Covid-19 and mortality. It represents the most cost-effective approach and should be largely promoted and incorporated in everyday practice. This is a booster that is needed at this unprecedented time and that may actually work to mitigate Covid-19.


  1. Puranik A, Lenehan PJ, Silvert E, Niesen MJM, Corchado-Garcia J, O’Horo JC, et al. Comparison of two highly-effective mRNA vaccines for COVID-19 during periods of Alpha and Delta variant prevalence [Internet]. 2021 Aug [cited 2021 Aug 16] p. 2021.08.06.21261707.
  2. Watanabe M, Balena A, Tuccinardi D, Tozzi R, Risi R, Masi D, et al. Central obesity, smoking habit, and hypertension are associated with lower antibody titres in response to COVID-19 mRNA vaccine. Diabetes Metab Res Rev. 2022;38:e3465. Article PubMed Google Scholar 
  3. Merino J, Joshi AD, Nguyen LH, Leeming ER, Mazidi M, Drew DA, et al. Diet quality and risk and severity of COVID-19: a prospective cohort study [Internet]. 2021 Jun [cited 2021 Aug 16] p. 2021.06.24.21259283.
  4. Kim H, Rebholz CM, Hegde S, LaFiura C, Raghavan M, Lloyd JF. et al. Plant-based diets, pescatarian diets and COVID-19 severity: a population-based case-control study in six countries. BMJ Nutr Prev Health. 2021;4:257–266. PubMed PubMed Central Google Scholar 
  5. GBD 2017 Diet Collaborators. Health effects of dietary risks in 195 countries, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2019;393:1958–72.Article Google Scholar 
  6. Kahleova H, Levin S, Barnard N. Cardio-Metabolic Benefits of Plant-Based Diets. Nutrients. 2017;9:E848.Article Google Scholar 
  7. Appel LJ. Dietary patterns and longevity: expanding the blue zones. Circulation. 2008;118:214–5.Article Google Scholar 
  8. Willcox DC, Willcox BJ, Todoriki H, Suzuki M. The Okinawan Diet: Health Implications of a Low-Calorie, Nutrient-Dense, Antioxidant-Rich Dietary Pattern Low in Glycemic Load. J Am Coll Nutr. 2009;28:500S–516S. sup4.CAS Article Google Scholar 
  9. Japan: coronavirus cases and deaths by prefecture [Internet]. Statista. [cited 2021 Aug 16].

Download references


This work was funded by the Physicians Committee for Responsible Medicine.

Author information


  1. Physicians Committee for Responsible Medicine, 5100 Wisconsin Ave, N.W. Ste.400, Washington, DC, 20016, USAHana Kahleova & Neal D. Barnard
  2. George Washington University School of Medicine and Health Sciences, Washington, DC, USANeal D. Barnard


HK has drafted the paper and NDB has critically reviewed and revised it. Both authors have approved the final version of the paper.

Corresponding author

Correspondence to Hana Kahleova.

Ethics declarations

Competing interests

Dr HK works at the Physicians Committee for Responsible Medicine. Dr NDB serves without financial compensation as president of the Physicians Committee for Responsible Medicine and Barnard Medical Center, nonprofit organizations providing education, research, and medical care related to nutrition. He writes books and gives lectures related to nutrition and health and has received royalties and honoraria from these sources.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit

Reprints and Permissions

Leave a Reply

Your email address will not be published.